A new high-throughput screening methodology for the discovery of cancer-testis antigen using multi-omics data

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Dandan Li, Lingyun Xia, Xiangang Zhang, Yue Liu, Zidi Wang, Qiwei Guo, Pan Huang, Weidong Leng, Shanshan Qin

Published: 01 Jan 2024, Last Modified: 25 Jul 2025Comput. Methods Programs Biomed. 2024EveryoneRevisionsBibTeXCC BY-SA 4.0
Abstract: Highlights•We propose a new method for high-throughput screening of CTA and validate its effectiveness.•We identified serine protease PRSS41 as a novel cancer-testis antigen that can serve as a target for immunotherapy of gastrointestinal cancer.•PRSS41 can serve as a diagnostic biomarker that is frequently overexpressed in gastrointestinal cancer due to promoter DNA hypomethylation.•Promoter DNA methylation level of PRSS41 (cg08104780) predicts poor prognosis in gastric cancer.