FutureMorph: Toward Predicting Future Deformation Fields in Longitudinal Imaging

Samah Khawaled, Rudolf Leonardus Mirjam Van Herten, Rachit Saluja, Mert R. Sabuncu

Keywords: Longitudinal MRI, Deformation Field, Neurodegeneration, Aging, Conditional Modelling

Abstract: Understanding how anatomy evolves over time is essential for tracking disease progression, quantifying risk, and studying healthy development and aging. Existing approaches either synthesize future images without modeling geometry or perform longitudinal registration that require follow-up scans. We introduce FutureMorph, a framework that treats longitudinal forecasting as metadata-conditioned prediction of future diffeomorphic deformation fields. Given a baseline image (e.g., a brain MRI) and subject-level metadata (age, sex, and clinical variables), FutureMorph predicts time-indexed, subject-specific diffeomorphic deformation fields that explicitly describe future anatomical change. We employ a metadata-conditioned U-Net to estimate stationary velocity vector fields, which are integrated into smooth diffeomorphisms and applied using a spatial transformer to synthesize future images. Experiments on the OASIS-3 dataset show that our framework produces clinically meaningful predicted deformations and realistic future scans, capturing aging- and interval-dependent trajectories. Our work provides a new perspective for longitudinal imaging studies by unifying image synthesis and deformation modeling.

Primary Subject Area: Image Registration

Secondary Subject Area: Application: Neuroimaging

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Originality Policy: Yes

Single-blind & Not Under Review Elsewhere: Yes

LLM Policy: Yes

Submission Number: 135