A Statistical Framework to Identify Cell Types Whose Genetically Regulated Proportions are Associated with Complex Diseases

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Hongyu Zhao, Wei Liu, Wenxuan Deng, Ming Chen, Zihan Dong, Biqing Zhu, Zhaolong Yu, Daiwei Tang, Maor Sauler, Louise Wain, Michael Cho, Naftali Kaminski

Published: 10 Mar 2021, Last Modified: 08 Feb 2026CrossrefEveryoneRevisionsBibTeXCC BY-SA 4.0
Abstract: Finding disease-relevant tissues and cell types can facilitate the identification and investigation of functional genes and variants. In particular, cell type proportions can serve as potential disease predictive biomarkers. Here, we introduce a novel statistical framework, cell-type Wide Associa...