ICAM-reg: Interpretable Classification and Regression with Feature Attribution for Mapping Neurological Phenotypes in Individual Scans

Cher Bass, Mariana da Silva, Carole H. Sudre, Logan Zane John Williams, Petru-Daniel Tudosiu, Fidel Alfaro-Almagro, Sean P. Fitzgibbon, Matthew Glasser, Stephen M. Smith, Emma Claire Robinson

Keywords: Interpretable, Classification, Regression, Deep Generative Networks

TL;DR: This paper presents a framework for regression with feature attribution using deep generative methods.

Abstract: Feature attribution (FA), or the assignment of class-relevance to different locations in an image, is important for many classification and regression problems but is particularly crucial within the neuroscience domain, where accurate mechanistic models of behaviours, or disease, require knowledge of all features discriminative of a trait. At the same time, predicting class relevance from brain images is challenging as phenotypes are typically heterogeneous, and changes occur against a background of significant natural variation. Here, we present an extension of the ICAM framework for creating prediction specific FA maps through image-to-image translation.

Paper Type: both

Primary Subject Area: Interpretability and Explainable AI

Secondary Subject Area: Application: Radiology

Paper Status: based on accepted/submitted journal paper

Source Code Url: https://github.com/CherBass/ICAM

Data Set Url: https://www.ukbiobank.ac.uk/

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Community Implementations: [ 1 code implementation](https://www.catalyzex.com/paper/arxiv:2103.02561/code)