Interrelation Among the Developmental Trajectories of Brain, Cognition and Behavior During Adolescence

Uwasila Binte Munir, Dawn M Jensen, Aidan Troha, Jingyu Liu

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Keywords: Brain Maturation, Adolescence, Regularized Canonical Correlation Analysis, Cognition, Behavior

Abstract:

During adolescence, the dynamic change of brain
structure and function underlies the rapid maturation of cog
nition and behavior. However, it remains underexplored how
distinct regional brain growth patterns are related to the devel
opment curves of cognition and behavior in large, longitudinal
samples. To investigate that, we employed data of 2553 children
from Adolescent Brain Cognitive Developmental study, including
brain morphological features, cognitive and behavioral measures
from ages 9-10 to 13-14 years old. Linear mixed effects model
and latent growth curve analysis were first used to estimate the
development trajectories of 302 brain features, 5 cognitive and
20 behavior measures. We then applied a regularized canonical
correlation analysis on the resultant trajectory characteristics of
brain features and those of cognition and behavior. Two pairs
of significant and robust intriguing associations were identified
between brain and behavior. The first pair of components
highlighted the association of the increasing rate of bilateral
cerebellar volume as well as cerebral white matter volume with
the decreasing rate of internalizing behavior problems. Whereas,
the second pair of components emphasized the relationship be
tween crystallized intelligence and cerebral white matter volume
as well as left and right ventral diencephalon volume at baseline.
These findings provide us a precise understanding of how brain
maturation is associated with cognition and emotional regulation.

Track: 3. Imaging Informatics

Registration Id: WDNNX24YV26

Submission Number: 286