Multimodal Disease Progression Modeling via Spatiotemporal Disentanglement and Multiscale Alignment

Chen Liu, Wenfang Yao, Kejing Yin, William K. Cheung, Jing Qin

Keywords: Longitudinal Multimodal Fusion; Disease Progression Modeling; Clinical Prediction

Abstract: Longitudinal multimodal data, including electronic health records (EHR) and sequential chest X-rays (CXRs), is critical for modeling disease progression, yet remains underutilized due to two key challenges: (1) redundancy in consecutive CXR sequences, where static anatomical regions dominate over clinically-meaningful dynamics, and (2) temporal misalignment between sparse, irregular imaging and continuous EHR data. We introduce $\texttt{DiPro}$, a novel framework that addresses these challenges through region-aware disentanglement and multi-timescale alignment. First, we disentangle static (anatomy) and dynamic (pathology progression) features in sequential CXRs, prioritizing disease-relevant changes. Second, we hierarchically align these static and dynamic CXR features with asynchronous EHR data via local (pairwise interval-level) and global (full-sequence) synchronization to model coherent progression pathways. Extensive experiments on the MIMIC dataset demonstrate that $\texttt{DiPro}$ could effectively extract temporal clinical dynamics and achieve state-of-the-art performance on both disease progression identification and general ICU prediction tasks.

Primary Area: Applications (e.g., vision, language, speech and audio, Creative AI)

Submission Number: 26252