Attentive cross-modal paratope prediction

Andreea Deac, Petar Veličkovi´c, Pietro Sormanni

Feb 12, 2018 (modified: Feb 12, 2018) ICLR 2018 Workshop Submission readers: everyone
  • Abstract: Antibodies are a critical part of the immune system, having the function of directly neutralising or tagging undesirable objects (the antigens) for future destruction. Being able to predict which amino acids belong to the paratope, the region on the antibody which binds to the antigen, can facilitate antibody design and contribute to the development of personalised medicine. The suitability of deep neural networks has recently been confirmed for this task, with Parapred outperforming all prior physical models. Our contribution is twofold: first, using just the antibody data, we outperform the results of Parapred by producing a model which is computationally significantly more efficient by using `a trous convolutions and self-attention. Secondly we implement cross-modal attention by allowing the antibody residues to attend over antigen residues. This leads to new state-of-the-art results on this task, along with insightful interpretations.
  • TL;DR: We use self and cross-modal attention to predict binding probabilities of antibody residues, obtaining state-of-the-art performance as well as new qualitative insights.
  • Keywords: à trous, antibody, attention, antigen, cross-modal, paratope, self-attention