EARS-UDE : Evaluating Auditory Response in Sensory Overload with Universal Differential Equations

Miheer Salunke, Prathamesh Dinesh Joshi, Raj Dandekar, Rajat Dandekar, Sreedath Panat

Additional Submission Instructions: For the camera-ready version, please include the author names and affiliations, funding disclosures, and acknowledgements.

Track: Track 1: Original Research/Position/Education/Attention Track

Keywords: Autism Spectrum Disorder (ASD), Auditory Sensory Overload, Universal Differential Equations (UDEs), Scientific Machine Learning (SciML), Personalized Computational Modeling, Neuroscience

TL;DR: EARS-UDE, a SciML framework combining differential equations with neural nets, models auditory adaptation in autism, improving performance by 90.8% while enabling interpretable, personalized risk assessment for sensory overload.

Abstract: Auditory sensory overload affects 50-70% of individuals with Autism Spectrum Disorder (ASD), yet existing approaches, such as mechanistic models (Hodgkin-Huxley-type, Wilson-Cowan, excitation-inhibition balance), clinical tools (EEG/MEG, Sensory Profile scales), and ML methods (Neural ODEs, predictive coding), either assume fixed parameters or lack interpretability, missing autism's heterogeneity. We present a Scientific Machine Learning approach using Universal Differential Equations (UDEs) to model sensory adaptation dynamics in autism. Our framework combines ordinary differential equations grounded in biophysics with neural networks to capture both mechanistic understanding and individual variability. We demonstrate that UDEs achieve a 90.8% improvement over pure Neural ODEs while using 73.5% fewer parameters. The model successfully recovers physiological parameters within the 2% error and provides a quantitative risk assessment for sensory overload, predicting 17.2% risk for pulse stimuli with specific temporal patterns. This framework establishes foundations for personalized, evidence-based interventions in autism, with direct applications to wearable technology and clinical practice.

Submission Number: 156