REPRESENTATIONAL ALIGNMENT OF GLOMERULI ACTIVATION IN MURINE OLFACTORY BULB

Vivek kumar Agarwal, Julia Manasson, Mario H. Garrido-Czacki, Ilia Sucholutsky

Track: tiny / short paper (up to 5 pages)

Domain: neuroscience

Abstract:

The presence of disease results in the production of odors different from the
healthy state, which can be detected by mice. Each odorant generates a unique
glomeruli activation pattern in the murine olfactory system. However, these
signals differ spatially and temporally across mice and capturing them is labor-
intensive. To optimize the process, glomeruli activation patterns for many odor-
ants could be mapped from a reference animal imaged on all available odorants to
target animals imaged on a subset of odorants. In our initial approach to develop
this method, we align the glomeruli activation patterns for 11 odorants between 2
mice using the optimal transport Sinkhorn algorithm.

Submission Number: 11