Dataset for N-ary Relation Extraction of Drug Combinations

Anonymous

Abstract: Combination therapies have become the standard of care for diseases such as cancer, tuberculosis, malaria and HIV. However, the combinatorial set of available multi-drug treatments creates a challenge, particularly in the presence of antagonistic drug combinations that may lead to negative patient outcomes. To assist medical professionals in identifying beneficial drug-combinations, we construct an expert-annotated dataset for extracting information about the efficacy of drug combinations from the scientific literature. Beyond its practical utility, the dataset also presents a unique NLP challenge, as it is the first relation extraction dataset consisting of variable-length relations. Furthermore, the relations in this dataset predominantly require language understanding beyond the sentence level, adding to the challenge of this task. We provide a strong baseline model and identify clear areas for further improvement. We release our dataset and code (https://anonymous.4open.science/r/drug-synergy-models--C8B7/README.md) publicly to encourage the NLP community to participate in this task.