Rapid and accurate prediction of protein homo-oligomer symmetry with Seq2Symm

Meghana Kshirsagar, Artur Meller, Ian Humphreys, Samuel Sledzieski, Yixi Xu, Rahul Dodhia, Eric Horvitz, Bonnie Berger, Gregory Bowman, Juan Lavista Ferres, David Baker, Minkyung Baek

Abstract: The majority of proteins must form higher-order assemblies to perform their biological functions. Despite the importance of protein quaternary structure, there are few machine learning models that can accurately and rapidly predict the symmetry of assemblies involving multiple copies of the sa...

External IDs:doi:10.21203/rs.3.rs-4215086/v1