Towards robust and generalizable representations of extracellular data using contrastive learning

Ankit Vishnubhotla, Charlotte Loh, Akash Srivastava, Liam Paninski, Cole Lincoln Hurwitz

Keywords: contrastive learning, representations, extracellular, high-density, spike sorting, cell-type classification, transformers, invariance

TL;DR: A contrastive learning spike featurization method for high-density extracellular recordings.

Abstract: Contrastive learning is quickly becoming an essential tool in neuroscience for extracting robust and meaningful representations of neural activity. Despite numerous applications to neuronal population data, there has been little exploration of how these methods can be adapted to key primary data analysis tasks such as spike sorting or cell-type classification. In this work, we propose a novel contrastive learning framework, CEED (Contrastive Embeddings for Extracellular Data), for high-density extracellular recordings. We demonstrate that through careful design of the network architecture and data augmentations, it is possible to generically extract representations that far outperform current specialized approaches. We validate our method across multiple high-density extracellular recordings. All code used to run CEED can be found at https://github.com/ankitvishnu23/CEED.

Submission Number: 14699