Crypto-ncRNA: Non-coding RNA (ncRNA) Based Encryption Algorithm

WangXu, YiquanWang, Tin-Yeh Huang

Track: tiny / short paper (up to 3 pages)

Keywords: Non-Coding RNA, Dynamic Folding, Physical Unclonable Functions, Post-Quantum Cryptography, Biomolecular Encryption

TL;DR: Crypto-ncRNA is a post-quantum encryption framework that harnesses the dynamic folding and inherent randomness of non-coding RNA to generate secure, hardware-bound cryptographic keys.

Abstract:

In the looming post‐quantum era, traditional cryptographic systems are increasingly vulnerable to quantum computing attacks that can compromise their mathematical foundations. To address this critical challenge, we propose crypto‐ncRNA—a bio‐convergent cryptographic framework that leverages the dynamic folding properties of non‐coding RNA (ncRNA) to generate high-entropy, quantum-resistant keys and produce unpredictable ciphertexts. The framework employs a novel, multi‐stage process: encoding plaintext into RNA sequences, predicting and manipulating RNA secondary structures using advanced algorithms, and deriving cryptographic keys through the intrinsic physical unclonability of RNA molecules. Experimental evaluations indicate that, although crypto‐ncRNA’s encryption speed is marginally lower than that of AES, it significantly outperforms RSA in terms of efficiency and scalability while achieving a 100% pass rate on the NIST SP 800-22 randomness tests. These results demonstrate that crypto‐ncRNA offers a promising and robust approach for securing digital infrastructures against the evolving threats posed by quantum computing.

Submission Number: 16