$\mu$PEN: Multi-class PseudoEdgeNet for PD-L1 assessmentDownload PDF

Published: 11 May 2021, Last Modified: 16 May 2023MIDL 2021 PosterReaders: Everyone
Keywords: PseudoEdgeNet, YOLO, PD-L1, lung cancer, histopathology
TL;DR: We extend PseudoEdgeNet for the multi-class task of PD-L1 stained cell detection in non-small cell lung cancer histopathology images and benchmark it against YoloV5.
Abstract: In this paper, we take the recently presented PseudoEdgeNet model to the level of multi-class cell segmentation in histopathology images solely trained with point annotations. We tailor its loss function to the challenges of multi-class segmentation and equip it with an additional false positive loss term. We evaluate it on the assessment of tumor and immune cells in PD-L1 stained lung cancer histopathology images, and compare it with YOLOv5.
Paper Type: validation/application paper
Primary Subject Area: Detection and Diagnosis
Secondary Subject Area: Application: Histopathology
Paper Status: original work, not submitted yet
Source Code Url: All code used for the YoloV5 model was directly taken from the open-source Github repo for Yolov5 by Ultralytics: https://github.com/ultralytics/yolov5 The code used for the PseudoEdgeNet model is currently a work in progress and contains multiple novel contributions that we do not fully elaborate on in this paper.
Data Set Url: The work in this paper is fully based on a dataset collected in-house at our hospital - we currently do not have permission to share this data in an open-source way.
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