Neural Correlates of Serial Dependence: Synaptic Short-term Plasticity Orchestrates Repulsion and Attraction

Xiuning Zhang, Xincheng Lu, Nihong Chen, Yuanyuan Mi

Keywords: serial dependence, short-term plasticity, continuous attractor neural networks, sensitivity and stability

Abstract: Serial dependence reflects how recent sensory history shapes current perception, producing two opposing biases: repulsion, where perception is repelled from recent stimuli, and attraction, where perception is drawn toward them. Repulsion typically occurs at the sensory perception stage, while attraction arises at the post-perception stage. To uncover the neural basis of these effects, we developed a two-layer continuous attractor neural network model incorporating synaptic short-term plasticity (STP). The lower layer, dominated by synaptic depression, models sensory processing and drives repulsion due to sustained neurotransmitter depletion. The higher layer, dominated by synaptic facilitation, models post-perception processing and drives attraction by sustained high neurotransmitter release probability. Our model successfully explains the serial dependence phenomena observed in the visual orientation judgment experiments, highlighting STP as the critical mechanism, with its time constants defining the temporal windows of repulsion and attraction. Furthermore, the model provides a neural foundation for the Bayesian interpretation of serial dependence. This study advances our understanding of how the neural system leverages STP to balance sensitivity in sensory perception with stability in post-perceptual cognition.

Primary Area: Neuroscience and cognitive science (e.g., neural coding, brain-computer interfaces)

Submission Number: 16435