Retrieval Augmented Thought Process for Private Data Handling in Healthcare

Thomas Pouplin, Hao Sun, Samuel Holt, Mihaela van der Schaar

Keywords: Privacy, Information-retrieval, Large Language Model, Question-Answering, retrieval based reasoning

TL;DR: The application of LLM in healthcare is limited by their inability to safely process private data. To address this limitation, this paper formulates and optimizes the retrieval-augmented thought generation of LLMs as a multi-step decision process.

Abstract: Large Language Models (LLMs) have demonstrated the strong potential to assist both clinicians and the general public with their extensive medical knowledge. However, their application in healthcare is constrained due to concerns about the privacy of data used in training, which prevents the integration of private and personal information because of security and ethical issues. Moreover, if their capabilities can be enhanced with information retrieval to access up-to-date knowledge, the current integration of LLMs with Information retrieval lacks robustness to imperfect retrieval, which can hinder their effectiveness and even reduce overall performance. In this work, we address this challenge by introducing the Retrieval-Augmented Thought Process (RATP). Given access to external knowledge, RATP formulates the thought generation of LLMs as a multiple-step decision process. To optimise such a thought process, RATP leverages Monte-Carlo Tree Search and learns a proxy reward function that permits cost-efficient inference. On a private dataset of electronic medical records, deliberately excluded from any LLM training set, RATP achieves 35% additional accuracy compared to in-context retrieval-augmented generation for the question-answering task.

Primary Area: alignment, fairness, safety, privacy, and societal considerations

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Submission Number: 9826